| ncRNA name | PLK1 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell lines Y79 and WERI-RB1 |
| Methods | siRNA transfection, qRT-PCR, Western blot, WST-8 assay, immunocytochemistry |
| Expression pattern | associated |
| Functional description | Polo-like kinase 1 inhibition may attenuate the thermoresistance of HT through the inactivation of HSF1 concomitant with reductions in HSPs and BAG3. The combination of PLK1 inhibition and HT may become an option for HT therapy in patients with retinoblastoma. |
| PubMed ID | 24366665 |
| Year | 2013 |
| Title | Inhibition of polo-like kinase 1 promotes hyperthermia sensitivity via inactivation of heat shock transcription factor 1 in human retinoblastoma cells. |
| Drug-related ncRNA | NO |
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